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KMID : 0980320190190020077
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Journal of Dental Anesthesia and Pain Medicine
2019 Volume.19 No. 2 p.77 ~ p.82
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Role of neuron and non-neuronal cell communication in persistent orofacial pain
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Iwata Koichi
Shinoda Masamichi
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Abstract
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It is well known that trigeminal nerve injury causes hyperexcitability in trigeminal ganglion neurons, which become sensitized. Long after trigeminal nerve damage, trigeminal spinal subnucleus caudalis and upper cervical spinal cord (C1/C2) nociceptive neurons become hyperactive and are sensitized, resulting in persistent orofacial pain. Communication between neurons and non-neuronal cells is believed to be involved in these mechanisms. In this article, the authors highlight several lines of evidence that neuron-glial cell and neuron macrophage communication have essential roles in persistent orofacial pain mechanisms associated with trigeminal nerve injury and/or orofacial inflammation.
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KEYWORD
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Cell Communication, Orofacial Persistent Pain, Spinal Trigeminal Nucleus, Trigeminal Ganglion
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